Laboratory of Molecular Biophysics Laboratory Journal 2001 Dr. M. E. M. Noble

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Martin Noble

Protein kinases, SH2-SH3 domains and arylamine N-acetyl transferase

Overview

Work in my group addresses structure function relationships of medically important proteins from three different areas: the eukaryotic cell cycle, cellular interactions with the extracellular matrix, and the enzyme arylamine N-acetyltransferase (NAT). We study these proteins by both experimental and theoretical approaches. Experimentally, proteins are subject to biochemical and biophysical characterisation, and structural analysis by X-ray crystallography or nuclear magnetic resonance (in collaboration with Dr. J. Werner and Prof I. Campbell). On the theoretical side, we have been developing tools to analyse the properties of protein surfaces.

Development of theoretical methods has centred on developing the molecular graphics program AESOP. AESOP interfaces with the program GRID to allow quantitative and qualitative analysis of the chemical character of protein surfaces. We have been exploring the use of this approach to identify probable sites of protein-protein interaction.

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