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Laboratory of Molecular Biophysics
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| Figure 1. Model and possible photochemical mechanism
for Drosophila Cryptochrome. A. Model of DmCry, based on the photolyase structures 1DNP (E. coli) and 1QNF (A. nidulans). The cofactor FAD, which was specifically included in this model, is shown. B. Possible light-induced reactions in DmCry, involving radical transfer along W422, W397 and W342. This scheme is proposed in analogy to the photochemistry observed in E. coli photolyase, where light-activation leads to oxidation and deprotonation of a surface exposed Trp residue (Aubert et al., 2000). |
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