With all of the sequences being collected in big programs like the human genome project and from individual work it should be possible to predict the structure of a protein from its sequence. However, there is a problem with this approach. The code by which DNA instructs the cell to make proteins was worked out very quickly. No similar code in the amino acid sequence of proteins which tells them how to fold has been recognised yet. We do not completely understand how the amino acid sequence causes the folding of the protein. This puzzle is called the "Protein Folding Problem".